Journal: Frontiers in Cellular and Infection Microbiology
Article Title: Evaluation of Beauvericin’s activity and mode of action against all life stages of L. tropica for cutaneous Leishmaniasis therapy
doi: 10.3389/fcimb.2025.1599766
Figure Lengend Snippet: Over-representation analysis (ORA) reveals conserved and stage-specific functional enrichments following BEA treatment in L. tropica . Bar plots depict the top significantly enriched Gene Ontology (GO) terms among differentially expressed genes (DEGs) in promastigotes and intracellular amastigotes. Notable enrichments include transmembrane transport, protein phosphorylation, oxidative stress response, and calcium-binding functions, which were subsequently used to define biologically coherent gene sets for GSEA analysis.
Article Snippet: Differentially expressed gene sets were identified through GSEA performed with RStudio version 4.3.0.
Techniques: Functional Assay, Phospho-proteomics, Binding Assay